diff --git a/pkgs/development/python-modules/maxminddb/default.nix b/pkgs/development/python-modules/maxminddb/default.nix
index 90acdef2d363..b5f7fb9d5db0 100644
--- a/pkgs/development/python-modules/maxminddb/default.nix
+++ b/pkgs/development/python-modules/maxminddb/default.nix
@@ -31,6 +31,10 @@ buildPythonPackage rec {
     "maxminddb"
   ];
 
+  # The multiprocessing tests fail on Darwin because multiprocessing uses spawn instead of fork,
+  # resulting in an exception when it can’t pickle the `lookup` local function.
+  disabledTests = lib.optionals stdenv.isDarwin [ "multiprocessing" ];
+
   meta = with lib; {
     description = "Reader for the MaxMind DB format";
     homepage = "https://github.com/maxmind/MaxMind-DB-Reader-python";