diff --git a/extras/libmemif/CMakeLists.txt b/extras/libmemif/CMakeLists.txt
index 8f057e98f3a..1526abdce3a 100644
--- a/extras/libmemif/CMakeLists.txt
+++ b/extras/libmemif/CMakeLists.txt
@@ -61,6 +61,17 @@ set(CMAKE_INSTALL_MESSAGE NEVER)
 find_package(Threads REQUIRED)
 include_directories(${CMAKE_THREADS_INCLUDE_DIRS})
 
+if(DEFINED LIBMEMIF_CACHELINE_SIZE)
+  # Cache line size assigned via cmake args
+elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "^(aarch64.*|AARCH64.*)")
+  set(LIBMEMIF_CACHELINE_SIZE 128)
+else()
+  set(LIBMEMIF_CACHELINE_SIZE 64)
+endif()
+
+message(STATUS "System Architecture: ${CMAKE_SYSTEM_PROCESSOR}")
+message(STATUS "Libmemif Cacheline Size: ${LIBMEMIF_CACHELINE_SIZE}")
+
 check_function_exists(memfd_create HAVE_MEMFD_CREATE)
 if(${HAVE_MEMFD_CREATE})
   add_definitions(-DHAVE_MEMFD_CREATE)
diff --git a/extras/libmemif/src/CMakeLists.txt b/extras/libmemif/src/CMakeLists.txt
index ddb8a52f82b..8b3223d0990 100644
--- a/extras/libmemif/src/CMakeLists.txt
+++ b/extras/libmemif/src/CMakeLists.txt
@@ -34,6 +34,7 @@ include_directories(${HEADERS_DIR})
 
 add_library(memif SHARED ${MEMIF_SOURCES})
 target_link_libraries(memif ${CMAKE_THREAD_LIBS_INIT})
+target_compile_definitions(memif PUBLIC MEMIF_CACHELINE_SIZE=${LIBMEMIF_CACHELINE_SIZE})
 
 find_library(LIB_BSD bsd)
 if(LIB_BSD)
diff --git a/src/plugins/memif/CMakeLists.txt b/src/plugins/memif/CMakeLists.txt
index b86d30adb97..4bbf6ba39db 100644
--- a/src/plugins/memif/CMakeLists.txt
+++ b/src/plugins/memif/CMakeLists.txt
@@ -33,3 +33,5 @@ add_vpp_plugin(memif
   INSTALL_HEADERS
   memif.h
 )
+
+add_compile_definitions(MEMIF_CACHELINE_SIZE=${VPP_CACHE_LINE_SIZE})